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Transfer Operations in Bioreactors

Learn the fundamental concepts and principles of transfer operations in bioreactors with this free online course.

Publisher: NPTEL
Mass and heat transfer are essential in our daily lives as well as in industry. This course introduces you to the fundamentals of transfer operations in bioreactors, such as molecular diffusion, and the principles of interphase mass transfer theory. It will be of interest to chemical engineering students and other professionals in bioprocessing technologies.
Transfer Operations in Bioreactors
  • Duration

    3-4 Hours
  • Students

  • Accreditation


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Mass and heat transfer are crucial because all the processes by which raw materials are converted to final products must undergo heat and mass transfer. The fundamental concepts, principles, and applications of heat and mass transfer processes - such as molecular diffusion, interphase mass transfer theory, and mass transfer coefficients - will be covered in this course. You will learn about molecular diffusion and its role in bioprocessing such as mixing and mass transfer across a phase boundary. Interphase mass transfers are of interest in separation processes. The theories of interphase mass transfer - such as the film and penetration theory - will be discussed. Learn how to measure oxygen uptake rate useful in assessing growth, viability, and metabolic activity. Uncover the mass transfer coefficient and determine cell concentration that can be supported by the fermenter's oxygen-transfer system. Factors affecting cellular oxygen demand and the steps for oxygen transport from gas bubble to cell are presented. Several common problems are solved to illustrate the concepts clearly.

Next, the factors affecting oxygen supply rate and the variables that can be manipulated to change the oxygen supply rate will be explained. Learn the equation for oxygen transfer rate such as the static and dynamic method. The correlation for mass transfer coefficient, the functions of an agitator, and how to determine power consumption by the impeller will be explored. Familiarize yourself with the classification of fluids based on their behaviours as Newtonian or non-Newtonian fluid and learn about Newton's law of viscosity, the power-law model, and time-dependent behaviour. You will study the common types of heat transfer operation in the fermentation process that include In situ batch sterilization of liquid medium and temperature control during reactor operation. Find out the different heat combustion of biomass, how to design batch heat exchanger and the model equation for the batch system. Heat treatment is one of the most widely used methods for the destruction of spoilage and micro-organisms, you will consider the sterilization time required for reducing the original number of viable cells and how heat is used in the destruction of micro-organisms. The general equation for temperature as a function of time during the heating and cooling periods of batch sterilization will be explained. Explore the key points in the design procedures of batch sterilization and then the continuous heat sterilization process used in industry such as the continuous steam injection with flash cooling. The main advantages of continuous sterilization compared to batch sterilization will be explored.

Mass transfer operations are largely the responsibility of chemical engineers, but practitioners from other engineering disciplines also find them necessary for their work. Practising engineers in chemistry and biotechnology, as well as medical researchers, will find this fundamental and technical information useful to refresh their knowledge and skills. This course will also provide bioprocessing students with the theoretical or analytical background to understanding heat and mass transfer operations in bioreactors as well as their applications. Boost your bioengineering knowledge and skills, by studying this invaluable course. Enrol today!

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