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Biointerface Engineering: Protein Aggregation and Biomaterials

Learn the basics of Biointerface Engineering - Protein Aggregation and Biomaterials - in this free online course.

Publisher: NPTEL
Injuries to the skin or any part of the body occur from time to time, and the body has its natural mechanisms for preventing or stopping bleeding and healing the wound. You have perhaps observed this occurrence and wondered how it happens. In this free online course, you will discover protein aggregation, which is crucial in forming a fibrin plug that covers and protects the wound from bacteria. Start this thrilling course today and learn more!
Biointerface Engineering: Protein Aggregation and Biomaterials
  • Duration

    4-5 Hours
  • Students

  • Accreditation






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Medical research is crucial, especially when it is geared towards finding a cure or vaccine for new diseases, as you may have observed in the past when new illnesses threaten millions of lives. Many disciplines are involved in this kind of research, and one of them is Biointerface Engineering. In this free online course, you will learn about Biointerface Engineering with a specific focus on Protein Aggregation and Biomaterials, analysing their role in the medical world. Firstly, you will be introduced to the processes involved in forming protein aggregates and the effects of protein aggregation. You will also discover the methods used to characterise protein aggregation and the factors affecting protein aggregation. Then, you will study the kinetics of protein aggregation, the various protein aggregation pathways, and the aggregation process in bulk. After that, you will explore the aggregation process on surfaces, followed by how to determine the rate of aggregation. The effects of surfaces on the aggregation of proteins will be discussed using the insulin model protein for illustration purposes. After that, the concept of modified surfaces will be introduced, and then the wettability of surfaces with mono and mixed Self-Assembled Monolayers (SAMs) will be presented.

Next, you will study the effect of surface roughness on adsorption and the therapeutic solution to the protein aggregation process. Then, you will learn about host responses to biomaterials under which surface-biomolecules interactions, host cell response and hemostasis will be explained in detail. The sequence of reactions that occur when the body detects an injury or intrusion by a foreign object will be explained. You will also discover the application of inflammation mediators while exploring the factors that affect the cell-surface interactions. Cell adhesion, a critical part of the wound-healing process, will be introduced, and you will study how it works and the characterisation of cell adhesion. The phenomenon of work of adhesion and cell adhesion kinetics will then be examined. Lastly, you will be introduced to biocompatibility, the different classes of biomaterials, and the techniques for assessing biocompatibility. The characteristic of cytotoxicity will be contrasted to that of cytocompatibility as the various biological responses are uncovered. Though these topics and terminologies seem complex, they will be related systematically using examples to enable you to comprehend and relate to your experiences in the real world.

As stated earlier, the importance of Biointerface Engineering in biomedical research cannot be overemphasised. This course is designed for practising and aspiring medical research, diagnostics, and pharmacology professionals. It is also intended to benefit those in the world of academia, including lecturers, tutors and research fellows. If you are a medical practitioner, a nurse, a clinical officer, or laboratory assistant, you will find this course refreshing as you grow your knowledge base and relate with your work experiences. The knowledge gained will reinforce the skills you already have and build a formidable résumé when coupled with your work experience. If you are a medical student or an aspiring professional in any of the fields mentioned above, this course will build a solid foundation for your future career. Start the course today.

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