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Diploma in Bioreactor Design

Learn the fundamental principles in designing batch, fed-batch and continuous bioreactors with this free online course.

Publisher: NPTEL
Many of the considerations of bioreactor design involve questions of mass transport and conditions under which cells are able to grow. This free online course will introduce you to the basic features of bioreactors and principles in the design of bioreactors. Find out what size of the reactor, type of reactor, or method of operation is best for a given duty or conversion. Start this course today and gain valuable knowledge on bioreactors.
Diploma in Bioreactor Design
  • Duration

    6-10 Hours
  • Students

  • Accreditation






View course modules


Bioreactor design involves various critical parameters. One class of reactors for different catalysts requires separate unit operations to start the reactor. The size and shape of a bioreactor differ to a great extent depending on the various applications in bioprocesses. This free online course introduces you to the unique features of bioreactors, typical bioreactors parts, and classifies them based on their modes of operation, process requirements, and method of cultivating culture. Find out what size of the reactor, type of reactor, or method of operation is best for a given duty or conversion. Learn the basic control systems for the operations of the bioreactors and the factors to consider before choosing a mode of operating bioreactors. The major parameters that characterize the performance of bioreactors and techniques to measure and control these parameters will be discussed. Discover how the environmental conditions inside the bioreactor, such as temperature, nutrient concentrations, pH, and dissolved gases affect the growth and productivity of the organisms. Learn mathematical models to facilitate data analysis and provide a strategy for solving problems encountered in fermentations. All the possible measurements of cell concentration by direct and indirect methods of growth kinetics will be treated in this section of the course.

You will learn the definition of fed-batch cultivation, ideal continuous stirred tank reactor, the objectives of running fed-batch operations, and their advantages. Familiarize yourself with microbial product formation, their classification, and how to demonstrate product formation growth rate. Uncover how the volume of biomass changes with time and the flow rate of the feed. You will use the performance equation of the batch fermenter to demonstrate how cell concentration will change with time. Determine the concentration and total amount of biomass, substrate concentration, and product concentration quasi-steady state. Estimate the batch culture time and the final biomass concentration, the final mass of cells in a reactor, and how much cell biomass can be produced annually. View a graphical representation of the relationship between cell density, nutrient concentration, and dilution rate. Also, learn the mode of operation for a chemostat and how to determine the productivity of a chemostat and steady-state substrate concentration. You will use the Monod equation to describe the stimulation of growth by the concentration of nutrients, substrate consumption, and bacterial growth. Comparison in productivity between a batch and continuous reactors and descriptions of the plug flow reactor will be discussed. A graph showing the change in the concentration of cells and substrate as a function of the residence time will be analyzed. 

The bioreactor is the heart of any biochemical process in which enzymes, microbial, mammalian, or plant cell systems are used for the manufacture of a wide range of useful biological products. The common goal in bioreactor design is to develop a reactor that provides a prolonged, sterile, culture environment with efficient mixing and oxygen transfer without producing excessive foam and hydrodynamic shears. The main function of a properly designed bioreactor is to provide a controlled environment to achieve optimal growth and product formation in the particular cell system employed. The decisions made in the design of the bioreactor have a significant impact on the overall process performance. The success of a bioprocess depends critically on the good design and operation of the bioreactor. By completing this course, you will have crucial skills and knowledge which is in high demand in the field of biotechnology engineering. The course is suitable for students interested in the field of bioengineering, chemical engineering, or any other related discipline. Professionals such as medical researchers, engineers, and others who are interested in refreshing their knowledge and skills will find this course beneficial. Enroll today and jump-start your career.

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