An Introduction to DNA Damage
In this free online course, you will learn about DNA damage and repair, lesions, mutation of the genome and cancer.Publisher: NPTEL
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This free online course explores the causes and chemistry of DNA damage and lesion formation, which often leads to mutation of the genome and cancer. You will learn how DNA damage occurs and how the damaged DNA plays a role in developing mutations in the genome. You will see the structural changes in nucleobases that induce the mutations in the genome, which in turn is the reason for cancer.
Next, you will learn about the different kinds of lesions formed due to DNA damage and the chemistry behind their formation. The course goes on to deal with photochemical reactions in the cell, the different DNA-induced photoproducts and how they cause mutations of the genome. Finally, you will learn about the methods by which the eukaryotic cell detects and repairs damages or lesions as well as the DNA repair process in plants and lower organisms.
This is a video-based course presented by a renowned teacher of biochemistry and will be immensely useful to anyone who wishes to pursue a career in genetics, biochemistry, medicine or pharmaceuticals. The course provides valuable insights into historical as well as modern trends in bio-chemical research and laboratory techniques. Why wait? Start today and enhance your knowledge of DNA damage and repair in biological cells.Start Course Now
Once you have completed this course, you should be able to:
- Identify the causes of DNA damage and mutations
- Discuss the causes of the formation of lesions
- Explain the role of Reactive Oxygen Species (ROS) in mutations of the genome
- Recognize the structural changes in DNA nucleobases caused by UV radiation
- Discuss the various methods of DNA repair in cells
- Outline the process of DNA repair in plants and lower organisms.
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