Immunology - Fundamentals in Antibody Structure
In this free online immunology course, learn about the different ways in which antigens can bind to antibodies.Publisher: NPTEL
CertificationView course modules
Be introduced to the functions carried out by the antibody molecules based on their Y-shaped structure in this free immunology course. You will learn about the composition of protein chains in immunoglobulin molecules and the structure of the immunoglobulin constant and variable domains. This course is arranged systematically and presented clearly so you will easily be able to understand the concepts discussed.
Next, the material will explain the process of determining the specificity for an antigen, based on the variation in the sequences of the antibody V domains. It then demonstrates the relationships between a light-chain variable region’s antigen-binding site, its domain structure, and the gene that encodes it. The course emphasizes the recombination signal sequences (RSS) that flank the gene segments by encoding the V, D, and J regions of immunoglobulins.
Finally, you will learn about the enzymatic steps involved in the V-region rearrangement of gene segments. The contribution to the diversity of the third hypervariable region based on the variable addition and subtraction of nucleotides at the junctions between gene segments is also discussed. This course, ‘Immunology - Fundamentals in Antibody Structure’, is an informative study guide which will interest students studying biotechnology, life sciences and genetic engineering. Sign up for this course now and start learning today!Start Course Now
Antibody Structure and Diversity
Antibody Structure and Diversity – Learning Outcomes
Structure of Antibody
Antigen Recognition by T-Cells
Primary Immunoglobulin Gene Rearrangement
Rearrangement of V, D, and J Gene Segments
Enzymatic Mechanisms in V-Region Rearrangement
T-Cell Receptor Gene Rearrangement
Antibody Structure and Diversity – Lesson Summary
By the end of this module, you will be able to:
- Outline the structure of a typical antibody molecule
- Discuss the different ways in which antigens can bind to antibodies
- Explain the process of determining the specificity for an antigen
- Summarize the rearrangement process of the primary immunoglobulin gene
- Discuss the enzymatic steps involved in V-region rearrangement of gene segments
- Define the concept of 'somatic hypermutation'
- Describe the gene rearrangement process of the T-cell receptor
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