In this module, you will study the in vivo procedures for modifying genomic DNA sequences, the RNA-mediated gene modulation and chromosomal gene copy number control techniques. The advantages of the CRISPR-Cas system and the successful application of the Cas9-based genome editing technology for eukaryotic cell improvement will be discussed.

In this module, the methods for overcoming the challenges of large-scale biofuel production will be disclosed. Study the systems for converting lignocellulosic raw materials to ethanol, and the products value-addition strategies. The applications of systemic metabolic engineering for high-yield amino acids strains development will also be taught.