Understanding Antibody Diversity in Immunology
Learn about the generation of antibody diversity and the properties of immunoglobulins in this free online course..
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Be introduced to the properties of human immunoglobulin isotypes antigen recognition by T-cell receptors. You will learn how the IgM and IgD immunoglobulins are derived from the same pre-mRNA transcript and expressed on the surface of mature B-cells. This complex material is arranged systematically and presented clearly so you will easily be able to understand the given concepts.
Next, it will explain the process of isotype switching and the different types of variation between immunoglobulins. The course then demonstrates the role of peptides binding and stabilizing the MHC molecule on the cell surface and the creation of new alleles, by copying sequences from one MHC gene to another. It emphasizes the direct binding of the superantigens to the T-cell receptors and MHC molecules.
Finally, you will learn about the process of generating peptides from the ubiquitinated proteins. The cessation of antigen processing in dendritic cells through the reduced expression of the MARCH-1 E3 ligase is also discussed. ‘Understanding Antibody Diversity in Immunology’ is an informative course that will interest students studying life sciences, genetic engineering and biotechnology.Start Course Now
Immunoglobulin Isotypes and Antigen Recognition
Immunoglobulin Isotypes and Antigen Recognition – Learning Outcomes
Structural Variation in Immunoglobulin Constant Regions
Structural Variation and Isotype Switching
MHC Molecules and Peptides
Antigen Recognition by T-Cell Receptors
Immunoglobulin Isotypes and Antigen Recognition – Lesson Summary
Major Histocompatibility Complex and T-Cell Receptor Ligands
Major Histocompatibility Complex and T-Cell Receptor Ligands – Learning Outcomes
Major Histocompatibility Complex
Alloreactivity and Superantigens
Summary of the Immune System
Major Histocompatibility Complex and T-Cell Receptor Ligands – Lesson Summary
By the end of this module, you will be able to:
- Outline the physical and functional properties of the human immunoglobulin isotypes
- Explain the process of isotype switching
- Identify the different classes of MHC molecules
- Describe the binding process of CD4 and CD8 on MHC molecules
- Outline the distinct distributions of MHC molecules on the cells
- Explain the functions of the major histocompatibility complex (MHC)
- Discuss the genetic organization of the major histocompatibility complex
- Summarize the functions of antigen presentation
- Describe the process of generating peptides from the ubiquitinated proteins
- Explain the steps of antigen processing for MHC Class II molecules
- Summarize the overall functions of the immune system
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