Antibody Diversity in Immunology | Free Online Course | Alison
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Understanding Antibody Diversity in Immunology

Learn about the generation of antibody diversity and the properties of immunoglobulins in this free online course..

Biology
Free Course
This free online course discusses the properties of the human immunoglobulin isotypes and the generation of α:β T-cell receptor ligands. You will learn how the CD4 and CD8 cell-surface proteins of T-cells directly contact the MHC molecules to make an effective response to the antigen. Further, the process of generating peptides from the ubiquitinated proteins and the cessation of antigen processing are also discussed.
  • Duration

    4-5 Hours
  • Certification

    Yes
  • Mobile Friendly

    Yes
  • Publisher

    NPTEL
  • Accreditation

    CPD

Description

Modules

Outcome

Certification

View course modules

Description

Be introduced to the properties of human immunoglobulin isotypes antigen recognition by T-cell receptors. You will learn how the IgM and IgD immunoglobulins are derived from the same pre-mRNA transcript and expressed on the surface of mature B-cells. This complex material is arranged systematically and presented clearly so you will easily be able to understand the given concepts.

Next, it will explain the process of isotype switching and the different types of variation between immunoglobulins. The course then demonstrates the role of peptides binding and stabilizing the MHC molecule on the cell surface and the creation of new alleles, by copying sequences from one MHC gene to another. It emphasizes the direct binding of the superantigens to the T-cell receptors and MHC molecules.

Finally, you will learn about the process of generating peptides from the ubiquitinated proteins. The cessation of antigen processing in dendritic cells through the reduced expression of the MARCH-1 E3 ligase is also discussed. ‘Understanding Antibody Diversity in Immunology’ is an informative course that will interest students studying life sciences, genetic engineering and biotechnology.

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Learning Outcomes

By the end of this module, you will be able to:


  • Outline the physical and functional properties of the human immunoglobulin isotypes
  • Explain the process of isotype switching
  • Identify the different classes of MHC molecules
  • Describe the binding process of CD4 and CD8 on MHC molecules
  • Outline the distinct distributions of MHC molecules on the cells
  • Explain the functions of the major histocompatibility complex (MHC)
  • Discuss the genetic organization of the major histocompatibility complex
  • Summarize the functions of antigen presentation
  • Describe the process of generating peptides from the ubiquitinated proteins
  • Explain the steps of antigen processing for MHC Class II molecules
  • Summarize the overall functions of the immune system

Certification

All Alison courses are free to enrol, study and complete. To successfully complete this Certificate course and become an Alison Graduate, you need to achieve 80% or higher in each course assessment. Once you have completed this Certificate course, you have the option to acquire an official Certificate, which is a great way to share your achievement with the world. Your Alison Certificate is:

Ideal for sharing with potential employers - include it in your CV, professional social media profiles and job applications
An indication of your commitment to continuously learn, upskill and achieve high results
An incentive for you to continue empowering yourself through lifelong learning

Alison offers 3 types of Certificates for completed Certificate courses:

Digital Certificate - a downloadable Certificate in PDF format, immediately available to you when you complete your purchase
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