Alison's New App is now available on iOS and Android! Download Now

Introduction to Bioreactor Design

Learn the core principles for designing the batch, fed-batch and continuous bioreactors in this free online course.

Publisher: NPTEL
The bioreactor design is a relatively complex engineering task, the design must satisfy user demands, which vary from user to user. A properly designed bioreactor provides a controlled environment to create products. This free online course will teach you the principles of designing bioreactors, their unique features, and how to operate basic control systems. Are you ready to start a career in bioengineering? Start learning today!
Introduction to Bioreactor Design
  • Duration

    3-4 Hours
  • Students

  • Accreditation






View course modules


The bioreactor is the core of industrial biotechnology practice today. This free online course will introduce you to a bioreactor, its unique features, and be able to identify consumer products that are made by industrial biotechnology. You will learn the advantages of choosing biotechnology over chemical synthesis and be able to operate the basic control systems of a bioreactor. Some important questions that must be answered to run an efficient bioprocess will be considered. Significant factors that you must consider before choosing a mode of operation in bioreactor will be covered., You will be able to classify bioreactors based on their modes of operations, process requirements, and method of cultivating culture. Next, you will examine the operating modes of common bioreactors such as the batch, fed-batch, and continuous bioreactors. You will also be able to determine the volume of the reactor needed to meet the production target and also calculate the productivity for the reactor volume, process kinetics, and conversion. The classification of growth kinetics based on the relationship between product synthesis and energy generation in the cell will be explained. The course goes on to deal with unstructured and distributed empirical models, you will learn the underlining assumptions in this model. What are the different phases in batch culture? This course will help you examine these phases, learn the terminologies for microbial growth, and discover the relationship between the specific growth rate of a microbe and its substrate concentration.

Next, you will be able to apply mathematical models for bioreactors, analyze their behavior and specify operating parameters. Discussions on many numerical problems using equations such as the Monod equation, design, and performance equation of batch fermenter, will be delivered. Some improvements made to the Monod equation will be shown and you will become capable of using it to determine the growth rate of microorganisms. You will observe a drawing of a typical growth curve for a bacterial population and a discussion of what batch growth yield coefficients are. Discover how the environmental conditions inside the bioreactor, such as temperature, nutrient concentrations, pH, and dissolved gases affect the growth and productivity of the organisms. You will learn how to calculate biomass production, estimate the time required for biomass production, and outline the implications of cell density. All the possible measurements of cell concentration by direct and indirect methods of growth kinetics are also covered in this section of the course.

In recent times, the field of Biology has seen many changes and advancements. Bioreactors are designed to sustain knowledge in bioprocesses. You will study information on fermentation process kinetics which is potentially valuable for the improvement of batch process performance. Learn mathematical models to facilitate data analysis and provide a strategy for solving problems encountered in fermentations. The design of a bioreactor involves various critical parameters and also the size and shape of a bioreactor differ to a great extent depending on the various applications in bioprocesses. You will identify the major parameters that characterize the performance of bioreactors and techniques to measure and control these parameters. By completing this course, you gain valuable insights into the principles of bioreactor design and also develop your appreciation and understanding of the subject discussed. Why wait? Start today and enhance your knowledge of bioreactor design.

Start Course Now