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Biointerface Engineering: Surface Interactions and Modifications

Learn the basics of Biointerface Engineering - Surface Interactions and Modifications - in this free online course.

Publisher: NPTEL
Medical solutions such as implants in the body are crucial in curing certain injuries, fractures and defects. Have you ever wondered how non-biological implants work in harmony with the body to achieve the intended purpose? You will study the modifications made on such implants to make them biocompatible in this free online course. The course is intended for both practising and aspiring professionals in the medical field. Start this course today!
Biointerface Engineering: Surface Interactions and Modifications
  • Duration

    10-15 Hours
  • Students

  • Accreditation






View course modules


Medical treatments are based on scientific principles that have been tested over many years. In this free online course, you will learn about the systems and scientific principles that are crucial in enabling the functioning of healing mechanisms and the use of bodily implants, among other medical interventions. First, you will be introduced to the process of protein aggregation, the methods used in the characterisation of protein aggregation and the factors affecting the aggregation process. After that, you will learn about the kinetics of protein aggregation, the protein aggregation pathways and the determination of aggregation rate. Then, you will study the effects of surfaces on the aggregation of proteins, where the Insulin model protein will be examined. Further, you will discover the impact of surface roughness on adsorption and the therapeutic solution to the protein aggregation process. The surface-biomolecules interactions, host cell response, and the hemostasis process will be explained. You will also study the sequence of reactions and the factors that affect the cell-surface interactions. Then, you will learn about host responses to biomaterials, surface-biomolecules interactions, host cell response and the hemostasis process.

Next, you will study the cell adhesion mechanism and the biocompatibility of biomaterials. Then, you will be introduced to the practice of surface modification, objectives of surface modification, and surface modification approaches. You will also study the techniques used in surface improvement, the physiochemical properties of surfaces, and the challenges faced in surface modification of biomaterials. The use of calcium phosphates in coating titanium alloys will be discussed, followed by cell adhesion and the relationship between surface roughness and wettability. After that, you will uncover the methods used to characterise surfaces, the microscopic and spectroscopic techniques, their resolution and their accuracy. Then, you will learn about Self-Assembled Monolayers (SAMs), their formation and the factors affecting their formation. The effects of modification on interface properties will be unveiled, followed by the surface functionalisation of titanium alloys and surface modifications of titanium-based substances. You will also study the effect of surface energy, protein adsorption and secondary structure.

Proteins are the building blocks of life. Therefore, understanding what they are made of and their properties are crucial in medicine. Professionals in the medical world also need to be well-versed with the behaviour of implants in the human body, especially for orthopaedics, cardiologists and general practitioners. This course will equip you with the required knowledge, information and skills on Biointerface Engineering with a specific focus on protein aggregation, biomaterials and modification of surfaces as described above. Therefore, if you are a medical practitioner, you will find this course quite insightful. You will acquire more knowledge that will resonate with your current practice and build a formidable résumé when coupled with your work experience. If you would like to become a doctor, a nurse, a clinical officer or a clinician, this course will provide you with a firm foundation for launching your career. You will find it exciting and inspiring as you gather new knowledge and skills. So why wait? Start this course today!

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