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Design of Batch Bioreactors - Lesson Summary

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Key points from this module are:

Cell growth kinetics is the rate of cell growth and how it is affected by various chemical and physical conditions.

Measurement of cell concentration can be done using the direct such as dry weight, optical density and indirect method.
Unstructured and distributed model`s assumptions Include the following:

• Cell weight/cell number is increasing at the same rate as all its components
• The cell suspension is homogeneous
• Only one medium component is limiting the reaction rate

Monod equation is the mathematical model for the growth of microorganisms. Monod equation has the same form as the Michaelis-Menten Equation.

The Batch growth kinetics of a microbe follows a growth curve with lag phase as the initial phase during which cells adapt to a new environment.

There are different growth phases in batch culture which are:
• Lag phase
• Accelerated growth phase
• Exponential growth phase
• Decelerated growth phase
• Stationary phase
• Death phase

Terminologies for microbial growth are:
• Growth rate based on cell number and cell weight can be assumed to be equal in exponential growth phase
• Microbial growth, product formation and substrate utilization rates are usually expressed in the form of specific rates.
• Division rate is constant in exponential phase while growth rate is not

Major categories in microbial production formation are:
• Growth associated product formation
• Non-growth associated product formation
• Mixed growth associated product formation