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Early Mammalian Development Biology - Lesson Summary

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The key points from this module are:
The mammalian embryo obtains nutrients from the mother. This necessitates anatomical changes like:

Expansion of the oviduct into the uterus
Fetal organs (organs needed specifically to assist with a fetus development)


Birds and mammals are from reptilian ancestors.

WNT proteins induce the trophoblast to secrete a set of proteases that digest ECM and enable the embryo to bury itself in the uterine wall.

Trophoblast cells give rise to Cytotrophoblasts and Syncytiotrophoblasts

The Hox code hypothesis says that certain combinations of Hox genes specify a particular region of the anterior-posterior axis.

The main events of gastrulation are:
Endoderm and mesoderm form from epiblast.
Both types of cells migrate through the primitive streak.
Migrating epiblast cells lose E- cadherin and detach from neighbouring cells.
FGF Coordinate the cell specification and migration during gastrulation.