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Biomedical Polymers and Drug Conjugates - Lesson Summary

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Lesson Summary:

Page 1:
Biopolymers - Polymers that can be safely used in biological or medical applications. Polymers that are naturally present in organisms are called biopolymers.

Desirable Properties - Non-immunogenic
Non toxic
Easily tailored for specific applications
Conductive of easy scale-up (mass production)
Synthetic biopolymers
Chemically synthesized polymers
Designed specifically for particular usage including bio-molecule delivery, implants, tissue engineering , wound dressing and prosthetics
Natural biopolymers
Occur Naturally
Isolated and purified for biomedical usage including drug deliver, tissue engineering and wound application
Diffusion:
Fick's Law- Diffusion is defined as the movement of solute molecules from a higher to a lower concentration gradient.

Page 2:
Controlled Release: Basic Kinetics
Zero Order Release- Rate of drug release in independent of the mass of drug remaining in the device

First Order Release: Rate of drug release is proportional to the amount of drug remaining within the implant
Reservoir System:
A supersaturated drug reservoir, surrounded by non-degradable polymer membrane

Could have planar configuration or reservoir above a polymer membrane
Could have cylindrical configuration
Most commonly used polymers: Silicone Elastomers, EVAc
Could achieve nearly constant release rates
Advantages
Zero order release
Easy to control kinetics by device design parameters
Disadvantages
Non-degradable, must be removed
Impermeable to high molecular weight drugs
Leaks can be dangerous
Cost of surgeries