Molecular Probes | Lesson Summary

Set your study reminders

We will email you at these times to remind you to study.

Monday

Reminder set

-

7am

+

Tuesday

Reminder set

-

7am

+

Wednesday

Reminder set

-

7am

+

Thursday

Reminder set

-

7am

+

Friday

Reminder set

-

7am

+

Saturday

Reminder set

-

7am

+

Sunday

Reminder set

-

7am

+

Two modified oligonucleotides which are of major use in biochemistry as molecular probes are PNA and LNA.
Normal DNA has a sugar-phosphate backbone, while PNA has a peptide backbone; both of them have nucleic acids.
LNA has a rigid, locked sugar structure.
Both PNA and LNA are more stable in living cells compared to a foreign DNA.
Both PNA and LNA are target-selective.
Depending on the number of sugar units present in a molecule, carbohydrates are of the following types:
Monosaccharides
Disaccharides
Oligosaccharides
Polysaccharides
Polysaccharides are typically large molecules present in different organisms as a major component of their structures.

Module 1: Molecular Probes

Module 1: Introduction to Biomolecules

Introduction to Biomolecules - Learning Outcomes

Importance of Biomolecules

DNA Double Helix: Chemical Parameters

DNA and Proteins

Introduction to Biomolecules - Lesson Summary

Module 2: Nucleic Acids, Proteins and Lipids

Nucleic Acids, Proteins and Lipids - Learning Outcomes

Amino acids and Proteins

Protein 3D structures, Folding and Denaturation

Chemical Synthesis of Pyrimidine Nucleobases

Nucleic Acids, Proteins and Lipids - Lesson Summary

Module 3: Synthesis of Nucleobases, Nucleosides and Nucleotides

Synthesis of Nucleobases, Nucleosides and Nucleotides - Learning Outcomes

Chemical Synthesis of Purine Nucleobases; Prebiotic Chemistry

Synthesis of Nucleosides

Solid-phase DNA Synthesis

Synthesis of Nucleobases, Nucleosides and Nucleotides - Lesson Summary

Module 4: DNA Replication

DNA Replication - Learning Outcomes

Chemistry and Biology of DNA Replication

Chemistry of Polymerase Chain Reaction

PCR: Major Components and Steps

Sanger's DNA Sequencing

DNA Replication - Lesson Summary

Module 5: DNA Sequencing

DNA Sequencing - Learning Outcomes

DNA sequencing: Maxam - Gilbert Method

Numerical Problems

Problems with Chemical Synthesis

DNA Sequencing - Lesson Summary

Module 6: DNA Damage

DNA Damage - Learning Outcomes

DNA Damage and Mutation

Photochemistry of Mutation

DNA Repair

DNA Damage - Lesson Summary

Module 7: Advanced Diploma in Biomolecules: Nucleic Acids and Peptides - First Assessment

Advanced Diploma in Biomolecules: Nucleic Acids and Peptides - First Assessment

Module 8: DNA to Proteins

DNA to Proteins - Learning Outcomes

Transcription

Translation

mRNA to Protein

DNA to Proteins - Lesson Summary

Module 9: Protein Sequencing

Protein Sequencing - Learning Outcome

Ribosome and Codon

Sanger's Method and Edman Degradation

Other Sequencing Methods

Protein Sequencing - Lesson Summary

Module 10: Chemical Synthesis of Peptides

Chemical Synthesis of Peptides - Learning Outcomes

Solution Phase Peptide Synthesis

Solid Phase Synthesis and Peptide-Based Therapeutics

Spectroscopic Techniques

Chemical Synthesis of Peptides - Lesson Summary

Module 11: Modern Techniques

Modern Techniques - Learning Outcomes

Spectroscopic Studies

Separation and Analytical Techniques

Introduction to Molecular Probes

Modern Techniques - Lesson Summary

Module 12: Molecular Probes

Molecular Probes - Learning Outcome

PNA and LNA

Carbohydrates

Molecular Probes - Lesson Summary

Module 13: Chemistry of Carbohydrates

Chemistry of Carbohydrates - Learning Outcome

Polysaccharides

Synthesis of Nanoparticles

Chemistry of Carbohydrates - Lesson Summary

Module 14: Advanced Diploma in Biomolecules: Nucleic Acids and Peptides - Second Assessment

Advanced Diploma in Biomolecules: Nucleic Acids and Peptides - Second Assessment

Course assessment

Advanced Diploma in Biomolecules: Nucleic Acids and Peptides - Course Assessment

Set your study reminders