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Module 1: Sistemi di consegna rispondenti e mirati

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Stimuli-Sensitive/ Responsive Delivery Systems
Magnetically controlled release systems
Ultrasonically controlled systems
Temperature-sensitive hydrogels (Positively and negatively thermosensitive)
pH-sensitive hydrogels
Ligand (such as glucose) sensitive hydrogels
Light sensitive hydrogels
Specific ion-sensitive hydrogels
Specific antigen-responsive hydrogels
pH-Responsive systems for intracellular drug delivery- pH-sensitive polymers, such as poly(propyl acrylic acid), PPAA, that become hydrophobic at the endosomal pHs and disrupt the endosomal membrane

Magnetically controlled release systems- Two critical factors that control release rates, Magnetic field characteristics and Mechanical properties of polymer matrix

Targeting Drug Delivery System
Active:
Lectin-carbohydrate interactions
Ligand-receptor interactions
Anti-body-antigen interactions
Passive:
EPR Effect
Tumour Environment
Direct local delivery
Aptamer
A short oligonucleotide that can fold into a unique tertiary structure
Recognizes a specific target ranging from small organic molecules to proteins to cells
Evolutional selection method, systematic evolution of ligands by exponential enrichment (SELEX)
Compared with an antibody, the aptamer does not have an Fc region, which interacts with soluble Fc receptors
Easier penetration due to low molecular weight
Nanotoxicology
- In general, nanomaterials can penetrate into smaller structures and move deeper into passageways and tissues than larger particles.
- High surface area so lot more reaction per unit area
- Production of reactive oxygen species