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Module 1: Responsive and Targeted Delivery Systems

    Study Reminders
    Support

    Stimuli-Sensitive/ Responsive Delivery Systems
    Magnetically controlled release systems
    Ultrasonically controlled systems
    Temperature-sensitive hydrogels (Positively and negatively thermosensitive)
    pH-sensitive hydrogels
    Ligand (such as glucose) sensitive hydrogels
    Light sensitive hydrogels
    Specific ion-sensitive hydrogels
    Specific antigen-responsive hydrogels
    pH-Responsive systems for intracellular drug delivery- pH-sensitive polymers, such as poly(propyl acrylic acid), PPAA, that become hydrophobic at the endosomal pHs and disrupt the endosomal membrane

    Magnetically controlled release systems- Two critical factors that control release rates, Magnetic field characteristics and Mechanical properties of polymer matrix

    Targeting Drug Delivery System
    Active:
    Lectin-carbohydrate interactions
    Ligand-receptor interactions
    Anti-body-antigen interactions
    Passive:
    EPR Effect
    Tumour Environment
    Direct local delivery
    Aptamer
    A short oligonucleotide that can fold into a unique tertiary structure
    Recognizes a specific target ranging from small organic molecules to proteins to cells
    Evolutional selection method, systematic evolution of ligands by exponential enrichment (SELEX)
    Compared with an antibody, the aptamer does not have an Fc region, which interacts with soluble Fc receptors
    Easier penetration due to low molecular weight
    Nanotoxicology
    - In general, nanomaterials can penetrate into smaller structures and move deeper into passageways and tissues than larger particles.
    - High surface area so lot more reaction per unit area
    - Production of reactive oxygen species