The process of mitosis [1] can be divided into identifiable phases
_(IMPAT)._
* Period between cell divisions, when cell grows, develops and carries
out its normal function, at the end of interphase DNA replication takes
place.
* Chromosomes become visible (using a light microscope) within the
cell's nucleus; each chromosome consists of two chromatids joined at the
centromere; centrioles of animal cells separate and move to poles of the
cell; spindle fibres form from the centrioles; nucleolus disappears and the
nuclear membrane breaks down.
Spindle fibres shown under an electron microscope
A centriole pair shown under an electron microscope
* Chromosomes line up across the middle, or equator, of the cell;
chromosomes attach to the spindle fibres at their centromeres.
Metaphase shown under an electron microscope
* Centromeres split; chromatids separate and are pulled away along the
spindle fibres (each chromatid can now be called a chromosome).
Anaphase shown under an electron microscope
* Two groups of chromosomes uncoil into tangles of chromatin; nuclear
membranes form around the two sets of material; mitosis is complete; the
daughter cells have the same complement of chromosomes as the parent cell.
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